Pycno-Vite

The formula per capsule

 

Coenzyme Q10 (as Q10Vital®)

100

mg

 

 

NRV

Pycnogenol®

20

mg

 

Vitamin B1

0.7

mg

64%

Vitamin B2

0.42

mg

30%

Vitamin B6

2

mg

143%

Vitamin B12

3.5

mcg

140%

 

NRV=Nutrient reference value

 

Recommended dosage: 1 or two, preferably with meals

 

Technical information

 

Pycnogenol®

 

A super antioxidant to protect against oxidative stress.

 

Pycnogenol®, an extract from the bark of the French maritime pine, is a powerful antioxidant, protecting cells from oxidative stress caused by free radicals. As a result, it helps create a balance of free radicals and antioxidants, an important factor in healthy immune function in aging and all other situations in which oxidative stress may play a role, such as intensive sport. In addition, Pycnogenol® has a beneficial effect on the vascular system by strengthening the vessel walls and improving microcirculation, i.e. blood flow in the capillaries. For this reason,Pycnogenol® can be used in conditions like

--tired legs, cold hands and feet, and

-- diabetes, to prevent complications based on micro- and macro-circulatory disorders affecting the eyes (retinopathy), the kidneys (nephropathy), the nervous system (neuropathy), the blood vessels (atherosclerosis), and the skin (ulcers).

-- Pycnogenol® is the only bioactive nutrient shown to significantly lower inflammatory marker CRP in patients with osteoarthritis (OA). The results of studies showed that patients with  osteoarthritis  who also had elevated CRP have increased cytokine levels and inflammatory changes indicative of synovitis compared with subjects with OA and lower CRP. Other joint destructive enzymes include collagenase, elastase, hyaluronidase and chondroitinases. Pycnogenol can inhibit these enzymes.

Further, it binds and protects collagen and elastin-the proteins found in the skin and joint-and it stimulates production of new collagen fibers, making the shin and joint more flexible.

 

Pycnogenol® is a registered trademark of Horphag Research Ltd. protected by U.S. patents #5,720,956 and #6,372,266, and other international patents.

 

Coenzyme Q10

 



Coenzyme Q10 is a compound with vitamin-like properties, which means it is mostly accessed from external sources and is highly effective even in small doses. It plays a key role in the energy production of living cells, a process taking place in tiny intracellular organs called mitochondria. This is where energy from the nutrients is transformed into chemical energy and partly stored in ATP molecules.

Since its discovery in 1957, coenzyme Q10 (or ubiquinone), essential for energy production by the cells, has been extensively studied. It has been shown to play a key role in the maintenance of general health and, as a powerful antioxidant, may also contribute to prevention of several diseases and chronic conditions.
In Japan, coenzyme Q10 has been widely consumed as a dietary supplement since 1960. In higher doses, it has been used as a medicine in conditions associated with myocardial insufficiency. 
Unlike genuine vitamins, coenzyme Q10 can be synthesised by the human body, but its production gradually declines with aging. There are individuals whose body fails to produce sufficient amounts of coenzyme Q10 even at a young age, a phenomenon due to genetic defect or inappropriate diet, manifested in conditions like fatigue or chronic cardiovascular disease developing at an early age. 

In addition to promoting energy production, coenzyme Q10 is also a potent antioxidant. It has been shown to help maintain sodium-potassium ATP-ase activity and stabilise calcium dependent ion channels in the cardiac muscle. As most cellular functions require adequate amounts of ATP, coenzyme Q10 is essential for the healthy functioning of nearly allhuman tissues and organs.With aging, it is increasingly difficult for the body to produce sufficient amounts of coenzyme Q10. The organ most dependent on coenzyme Q10 is the heart.

 

 

Vitamins B


Vitamins B are water-soluble compounds. A balanced and varied diet contains sufficient quantities of vitamins B and therefore can prevent a deficiency state. Vitamins B are particularly important for the nervous system, the gastrointestinal system and the skin.

 

Vitamin B1 contributes to

-normal energy metabolism,as well as cardiac and neural health.

Vitamin B2contributes to

-normal energy and iron metabolism

-normal psychic functions
-reduction of tiredness and fatigue
- protection of DNA proteins and lipids against oxidative damage
- healthy nervous system function.

Vitamin B6

- is essential for protein, carbohydrate and lipid metabolism, the production of certain neurotransmitters, and blood formation

- supports normal homocysteine metabolism.

Vitamin B12 contributes to

- normal neural and psychic functions

-normal homocysteine metabolism
- helps reduce tiredness and fatigue.

 

Termék képek ( doboz, flakon)

Die Formel pro Kapsel

 

Coenzym Q10 (als Q10Vital®) 100 mg

 

                                                                     NRV

Pycnogenol® 20 mg

Vitamin B1 0,7 mg                                       64%

Vitamin B2 0,42 mg                                    30%

Vitamin B6 2 mg                                        143%

Vitamin B12 3,5 mcg                                 140%

 

NRV = Nährstoffreferenzwert

 

Empfohlene Dosierung: 1 oder zwei, vorzugsweise bei Mahlzeiten

 

 

Technical information

 

Pycnogenol®

 

Super Antioxidans zum Schutz vor oxidativem Stress.

Pycnogenol® ist der Pflanzenextrakt aus der Rinde der französischen Strandkiefer mit starken Antioxidantien, und schützt die Zellen vor dem oxidativem Stress durch freien Radikalen. Es hilft bei dem Gleichgewicht der freien Radikalen und der Antioxidantien, und es ist wichtig für das Immunsystem bei der Alterung und in solchen Fällen, in denen der oxidative Stress eine Rolle spielen kann, zum Beispiel bei dem intensiven Sport. Außerdem unterstützt Pycnogenol® das Gefäßsystem und trägt zu der starken Gefäßwand und dem wirksamen Mikrokreislauf, also der Strömung des Blutes in den Kapillaren bei. Deshalb kann verwendet werden zum Beispiel bei

-- ermüdeten Beinen, kalten Händen und Füßen

-- bestimmten Krankheiten, wie zum Beispiel bei Diabetes in dem Kampf gegen der Bildung der auf Mikro-Makro-Kreislaufstörungen beruhenden Komplikationen (Augen-Retinophatie, Nieren-Nephropathie, Neuropathie des Nervensystems, Gefäßverkalkung-Atherosklerose, Ulkus der Haut).

Pycnogenol® registrierte Handelsmarke der Horphag Research Ltd., die mit dem US-Patent Nr. # 5.720.956 und # 6.372.266 sowie durch anderes internationales Patent patentiert wurde.

 

Coenzym Q10

Coenzym Q10 ist eine chemische Verbindung mit vitaminartigen Eigenschaften. Es bedeutet, dass wir es großenteils von äußeren Quellen gewinnen, und es auch in geringer Menge sehr wirksam ist. Es spielt eine wichtige Rolle bei der Energieerzeugung der Zellen, es erfolgt in dem innerhalb der Zellen befindlichen kleinen Organ, in den Mitochondrien. Hier wird aus der durch die Nahrung aufgenommenen Energie eine chemische Energie und wird teilweise mit Hilfe der ATP Moleküle gelagert. 

 

Zu der Energieerzeugung der Zellen istCoenzym Q10 (oder mit anderen Namen Ubiquinon) unerlässlich und steht seit der Entdeckung im Jahre 1957 im Mittelpunkt der Forschungen. Zahlreiche Beobachtungen haben bestätigt, dass es nicht nur bei dem Erhalten der allgemeinen Kondition eine Schlüsselposition hat, sondern wegen der Wirkung als starkes Antioxidans an der Vorbeugung von vielen Krankheitsbildern und chronischen Krankheiten eine Rolle spielen kann.

In Japan wurde es seit 1960 umfassend als Nahrungsergänzungsmittel, aber in größerer Dosiswird er auch als Medikament in den sich aus der ungenügenden Funktion des Herzmuskels ergebenden Krankheitsbildern verwendet. 

Der Organismus der Menschen kann es (in Gegenteil zu den echten Vitaminen) synthetisieren, aber mit zunehmenden Alter reduziert sich die Produktion vonCoenzym Q10 im Organismus. Es gibt Menschen, die wegen einem genetischen Fehler oder Ernährungsproblemen sogar im jungen Alter weniger Q10 erzeugen können, und sehr früh ernste Zeichen als Müdigkeit, und in der frühen Bildung der chronischen Herz-Kreislauferkrankungen auftreten. 

Coenzym Q10 nimmt an der Energieerzeugung teil und ist daneben starker Antioxidans.

 

--es wurde erwiesen, dass Q10-Coenzymdie Aufrechterhaltung der Aktivität von Natrium-Kalium- ATP im Herzmuskelbefördert und stabilisiert die kalziumabhängigen Ionenkanäle des Herzmuskels.

-zu den meisten Zellenfunktionen ist die entsprechende Menge von ATP unerlässlich, deshalb spielt Q10-Coenzym eine Schlüsselrolle bei der gesunden Funktion von fast allen menschlichen Geweben und Organen.

- mit zunehmendem Alter kann der OrganismusQ10-Coenzym immer schwieriger erzeugen. Von dem Q10-Coenzym hängt am meisten unser Herz ab.

 

Vitamine B


Vitamine B sind wasserlösliche Vitamine und können durch ausgeglichene, abwechslungsreiche Ernährung leicht zugeführt werden, so entsteht kein Mangelzustand. Es spielt eine große Rolle im Nervensystem, im Verdauungsapparat und bei der Haut.

 

B1 trägt

-zu dem normalen Energie-Stoffwechsel, sowie der normalen Funktion des Herzes und des Nervensystems bei

Vitamin B2 trägt

-zu dem normalen Energie- und Eisen-Stoffwechsel

-zu der normalen psychischen Funktion
-zu der Minderung der Müdigkeit und Erschöpftheit
-zum Schutz gegen oxidative Schädigung der DNA-Eiweiße und Lipide
-zu der normalen Funktion des Nervensystems bei

Vitamin B6

-unerlässlich unter anderem in dem Eiweiß-, Kohlenhydrat- und Fett-Stoffwechsel, bei der Bildung von bestimmten Neurotransmittern und der Blutbildung.

-trägt zu dem normalen Homocystein-Stoffwechsel bei

Vitamin B12-vitamin trägt zu:

-den normalen neurologischen und psychologischen Funktionen
-dem normalen Homocystein-Stoffwechsel
- der Minderung der Müdigkeit und Erschöpftheit bei. 

references

Pycnogenol® and Coenzyme Q10 enhance cardiovascular health synergistically. 
Watson, R.R. (2005)

Nutraceutical Synergism: Pycnogenol® and Coenzyme Q10 Enhance Cardiovascular Health. Evid. Based Integrative Med. 2(2): 67-70.


Pycnogenol® as a neutraceutical in cardiovascular health and diabetes (Review). 
Gulati, O.P. (2006)

The Nutraceutical Pycnogenol®: its role in cardiovascular health and blood glucose control. Biomedical Reviews 16: 49-57.


Pycnogenol® counteracts the constriction of blood vessels due to stress. The vaso-relaxant activity of Pycnogenol® is mediated through nitric oxide. 
Fitzpatrick, D.F., Bing, B. and Rohdewald, P. (1998)Endothelium-dependent vascular effects of Pycnogenol®.Journal of Cardiovascular Pharmacology, 32: 509-515.


Pycnogenol® helps fighting against heart disease by inhibiting adhesion and aggregation of platelets and improving microcirculatory blood flow in humans. 

Wang, S., Tan, D. , Zhao, Y., Gao, G., Gao, X. and Hu, L. (1999)The effect of Pycnogenol® on the microcirculation, platelet function and ischemic myocardium in patients with coronary artery diseases. European Bulletin of Drug Research, 7 (2): 19-25


Pycnogenol® helps to maintain a healthy circulation through vasodilatation, anti platelet aggregation, free radical scavenging and capillary sealing effects. The role of endothelial nitric oxide (NO) is also discussed. 
Rohdewald, P. (1999) Reducing the risk for stroke and heart infarction with Pycnogenol®. European Bulletin of Drug Research, 7 (2): 14-18.


Pycnogenol® improves endothelial function of hypertensive patients and helps to lower the dose of the antihypertensive drug (Nifedipine) when administered simultaneously
Liu, X., Wei, J., Tan, F., Zhou, S., Würthwein, G. and Rohdewald, P. (2004) Pycnogenol® French maritime pine bark extract, improves endothelial function of hypertensive patients. Life Sciences, 74: 855-862.


Pycnogenol® increases antioxidant capacity and lowers cholesterol in obese volunteers in a double-blind, placebo-controlled study. 
Devaraj, S., Vega-López, S., Kaul, N., Schönlau, F., Rohdewald, P. and Jialal, I. (2002)Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters plasma lipoprotein profile.Lipids 37 (10): 931-934.


Pycnogenol® increases red blood cell membrane fluidity and protects erythrocytes against oxidative stress. 
Sivonova, M., Waczulikova, I., Kilanczyk, E., Hrnciarova, M., Bryszewska, M., Klajnert, B. and Durackova, Z. (2004)The effect of Pycnogenol® on the erythrocyte membrane fluidity.Gen. Physiol. Biophysic, 23: 39-51


Pycnogenol® inhibits smoking induced platelet aggregation in dose-dependent manner in humans. The effect lasts for more than 6 days and unlike aspirin, it does not produce increase in bleeding time. 
Pütter, M., Grotemeyer, K.H.M., Würthwein, G., Araghi-Niknam, M., Watson R.R., Hosseini, S. and Rohdewald, P. (1999)Inhibition of smoking-induced platelet aggregation by Aspirin and Pycnogenol®.Thrombosis Research, 95: 155-161


Pycnogenol® inhibits smoking-induced increased levels of thromboxane B2, the noxious agent involved in the increased platelet reactivity/aggregation in smokers. These results explain the mechanism of anti-platelet aggregation activity of Pycnogenol® observed in smokers. 
Araghi-Niknam, M., Hosseini, S., Larson D., Rohdewald, P. and Watson R.R. (1999)Pine bark extract reduces platelet aggregation.Integrative Medicine, 2 (2/3). 73-77.


Pycnogenol® inhibits the angiotensin II converting enzyme (ACE) and produces a moderate hypotensive effect in rats. 
Blazso, G., Gaspar R., Gabor, M., Rüve H-J and Rohdewald, P. (1996)ACE inhibition and hypotensive effect of procyanidinis containing extract from the bark of Pinus pinaster Sol. Pharm. Pharmacol. Lett., 6(1): 8-11.


Pycnogenol® inhibits the most important pro-inflammatory enzymes, signalizing Pycnogenol's bioavailability. 
Schäfer, A., Chovanova, Z., Muchova, J., Sumegova, K., Liptakova, A., Durackova, Z., Högger, P. (2005)Inhibition of Cox-1 and Cox-2 activity by plasma of human volunteers after ingestion of French maritime pine bark extract (Pycnogenol)Biomedicine & Pharmacotherapy, 60: 5-9.


Pycnogenol® lowered LDL significantly in patients with chronic venous insufficiency while horse chestnut seed extract had no effect. 
Koch, R. (2002)Comparative study of Venostasin® and Pycnogenol® in chronic venous insufficiency.Phytotherapy Research 16: 1-5.


Pycnogenol® reduces blood pressure, as shown in a randomized, double-blind, placebo-controlled study performed in mildly hypertensive patients. Furthermore, Pycnogenol® significantly decreases the level of the vasoconstrictor factor (thromboxane) in blood of these patients. 
Hosseini, S., Lee, J., Sepulveda, R. T., Rohdewald, P., Watson, R. R. (2001)

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A randomized, double-blind, placebo-controlled, prospective, 16 week crossover study to determine the role of Pycnogenol® in modifying blood pressure in mildly hypertensive patients. Nutrition Research, 21: 1251-1260


Pycnogenol® supplementation lowered total cholesterol and LDL and increased HDL, resulting in a better atherosclerotic index. 
Durackova, Z., Trebaticky, B., Novotny, V., Zitnanova, I. and Breza, J. (2003)

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Lipid metabolism and erectile function improvement by Pycnogenol®, extract from the bark of Pinus pinaster in patients suffering from erectile Dysfunction - a pilot study.Nutrition Research, 23: 1189-1198.



Review of the positive effects of Pycnogenol® for cardiovascular health, based on the published clinical studies in the cardiovascular area. 
Watson, R.R. (2003)Pycnogenol® and cardiovascular health.Evidence Based Integrative Medicine, 1(1): 27-32.


Pycnogenol® stimulates synthesis of antioxidative enzymes inside cells of the arteries thereby doubling the amount of antioxidative enzymes. 
Wei, Z. H., Peng, Q. L. and Lau, B.H. S. (1997)Pycnogenol® enhances endothelial cell antioxidant defenses.Redox Report, 3(4): 219-224.

 

Nutr Res. 2008 May;28(5):315-20. doi: 10.1016/j.nutres.2008.03.003.

Reduction of cardiovascular risk factors in subjects with type 2 diabetes by Pycnogenol supplementation.

Zibadi S1Rohdewald PJPark DWatson RR.

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 M.R. Cesarone et al., “Kidney Flow and Function in Hypertension: Protective Effects of Pycnogenol in Hypertensive Participants—A Controlled Study,” J. Cardiovasc. Pharmacol. Ther. 15 (1), 41–46 (2010).

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S. Stuard,et al., “Kidney Function in Metabolic Syndrome may be Improved with Pycnogenol,Panminerva Med.52 (Suppl. 1–2), 27–32 (2010).

Selective induction of apoptosis in human mammary cancer cells (MCF-7) by pycnogenol. Anticancer Res. 2000 Jul-Aug;20(4):2417-20.Huynh HT1Teel RW.

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Pycnogenol® inhibits growth of ovarian cancer cells in vitro.

              Amber R. Buz’zard and Benjamin H. Lau. Proc Amer Assoc Cancer Res, Volume

45, 2004

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The caspase 3-dependent apoptotic effect of pycnogenol in human oral squamous cell carcinoma HSC-3 cells.In-Hyoung Yang,1,† Ji-Ae Shin,1,† Lee-Han Kim,1 Ki Han Kwon,2,* and Sung-Dae Cho1,* J Clin Biochem Nutr. 2016 Jan; 58(1): 40–47.

 

Some scientific basis for ingredient combination in Pycno-Vite +Q 0

Investigation of Pycnogenol® in combination with coenzymeQ10 in heart failure patients (NYHA II/III). Panminerva Med. 2010 Jun;52(2 Suppl 1):21-5

  • Coenzyme Q10 and Vitamin B6 Reduce Risk of Coronary Artery Disease

Lee BJ, et al. Nutr Res. 2012;10:751-6

The activities of coenzyme Q10 and vitamin B6 for immune responses.

Biochem Biophys Res Commun. 1993 May 28;193(1):88-92.Folkers K1Morita     MMcRee J Jr

Vitamins B6, B12, and folate: association with plasma total homocysteine and risk of coronary atherosclerosis.

Siri PW1Verhoef PKok FJ. J Am Coll Nutr. 1998 Oct;17(5):435-41.

· Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women. Rimm EB, Willett WC, Hu FB, et al JAMA. 1998; 279:359–364.

· Folate, vitamin B6, and B12 intakes in relation to risk of stroke among men. He K, Merchant A, Rimm EB, et al. Stroke. 2004; 35:169–174.

Improvement of visual functions and fundus alterations in early age-related macular degeneration treated with a combination of acetyl-L-carnitine, n-3 fatty acids, and coenzyme Q10.

Feher J1Kovacs BKovacs ISchveoller MPapale ABalacco Gabrieli COphthalmologica. 2005 May-Jun;219(3):154-66.

 

Coenzyme Q10 protects retinal cells from apoptosis induced by radiation in vitro and in vivo Matteo Lulli, Ewa Witort, Laura Papucci, Eugenio Torre, Nicola Schiavone

Massimo Dal Monte, Sergio Capaccioli. J Radiat Res (2012) 53 (5): 695-703.